Human fascioliasis is usually recognized as an infection of the bile ducts and liver, but infection in other parts of the body can occur.
In the early (acute) phase, symptoms can occur as a result of the parasite's migration from the intestine to and through the liver. Symptoms can include gastrointestinal problems such as nausea, vomiting, and abdominal pain/tenderness. Fever, rash, and difficulty breathing may occur.
During the chronic phase (after the parasite settles in the bile ducts), the clinical manifestations may be similar or more discrete, reflecting inflammation and blockage of bile ducts, which can be intermittent. Inflammation of the liver, gallbladder, and pancreas also can occur.