CAS No. 68-12-2

Dimethylformamide [HCON(CH)] is a colorless to pale-yellow liquid with a faint odor. It can harm the eyes, skin, lungs, liver, and heart. Workers may be harmed from exposure to dimethylformamide. The level of exposure depends upon the dose, duration, and work being done.

Dimethylformamide is used in many industries. It is used as an industrial solvent and in the manufacture of synthetic fibers, plastics, and other chemicals. Some examples of workers at risk of being exposed to dimethylformamide include the following:

  • Factory workers involved in plastics manufacturing
  • Employees exposed to certain industrial solvents
  • Workers involved in acrylic fiber spinning
  • Employees who work in pharmaceutical production

NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses dimethylformamide, please read chemical labels and the accompanying Safety Data Sheets for hazard information. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures.

The following resources provide information about occupational exposure to dimethylformamide. Useful search terms for dimethylformamide include “dimethyl formamide,” “n,n-dimethylformamide,” and “DMF.”

NIOSH Chemical Resources

Logo of NIOSH Pocket Guide

The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards.

Logo of Manual of Analytical Methods.Cdc-pdf[PDF - 26 KB]

The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed.

Logo of Health Hazard Evaluations consisting of three letters: HHE

The Health Hazard Evaluation Program (HHE) conducts onsite investigations of possible worker exposure to chemicals. Search the HHE database for more information on dimethylformamide.

Related NIOSH Resources

Selected Publications

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International Resources

Page last reviewed: November 2, 2018