Criteria for a Recommended Standard: Occupational Exposure to Diacetyl and 2,3-Pentanedione

October 2016
DHHS (NIOSH) Publication Number 2016-111
Diacetyl cover

Diacetyl and its substitute, 2,3-pentanedione, are widely used as flavoring compounds. The National Institute for Occupational Safety and Health (NIOSH) objective in establishing recommended exposure limits (RELs) for diacetyl and 2,3-pentanedione is to reduce the risk of respiratory impairment (decreased lung function) and the severe irreversible lung disease obliterative bronchiolitis associated with occupational exposure.

In this Criteria Document, NIOSH reviews the scientific literature concerning potential health effects, toxicology, and risk assessment pertaining to diacetyl and 2,3-pentanedione. Recommendations are provided on engineering controls, work practices, and personal protective equipment to prevent and control workplace exposures to diacetyl and 2,3-pentanedione.

This Criteria Document is contained in PDF files, for ease of handling. The following table of contents allows you to open or download individual sections or the entire Criteria Document:

Document Development History

Peer Review Plan

Page last reviewed: October 27, 2016