Research Data

Public use data sets from NIOSH research studies. Each data set also includes a detailed methodology and data dictionary.

Advanced Manufacturing

• Multi-Walled Carbon Nanotubes Induce Arachidonate 5-Lipoxygenase Expression and Enhance the Polarization and Function of M1 Macrophages in vitro
• Resolution of pulmonary inflammation induced by carbon nanotubes and fullerenes in mice: role of macrophage polarization
• Pulmonary toxicity and gene expression changes in response to whole-body inhalation exposure to multi-walled carbon nanotubes in rats
• Evaluation of pulmonary effects of 3-D printer emissions from acrylonitrile butadiene styrene using an air-liquid interface model of primary normal human-derived bronchial epithelial cells
• Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats
• Influence of impurities from manufacturing process on the toxicity profile of boron nitride nanotubes
• Revealing the structural and chemical properties of copper-based nanoparticles released from copper treated wood-dataset

Anthropometrics

• Firefighter body dimensions for updating safety specifications for fire apparatus and firefighter protective equipment
• Anthropometric database for the EMTs in the United States
• NIOSH anthropometric data and ISO Digital headforms

Chronic Disease

• High-fat western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis-dataset
• Effects of crystalline silica inhalation in a high-fat western diet-induced metabolic dysfunction rat model. i. silica alters adipose tissue function and inhibits western diet-induced systemic inflammation.
• Biological effects of crude oil vapor. IV. Cardiovascular effects
• Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression

Exposure Assessment

• NIOSH HHE Program: Deepwater Horizon response exposure monitoring data
• Controlled generation of peracetic acid atmospheres for the evaluation of chemical samplers
• Feasibility of a selective epoxidation technique for use in quantification of peracetic acid in air samples collected on sorbent tubes
• A field-portable colorimetric method for the measurement of peracetic acid vapors: A comparison of glass and plastic impingers

Hazardous Drug Exposure in Healthcare

• Evaluation of propylene glycol methyl ether as a potential challenge agent for leak detection of liquid and headspace from closed system drug transfer devices using Fourier transform infrared spectroscopy
• Source apportionment and quantification of liquid and headspace leaks from closed system transfer devices via selected ion flow tube mass spectrometry (SIFT-MS)

Immune and Dermal Diseases

• Antimicrobials and allergic disease: identifying novel biomarkers and mechanisms of action
• The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness
• Modeling neuroimmune interactions in human subjects and animal models to predict subtype specific multidrug treatments for Gulf War Illness
• MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8 and chemotactic activities in 4,4’-methylene diphenyl diisocyanate exposed macrophages
• Exposure to the antimicrobial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis
• Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone
• Exposure to the immunomodulatory chemical triclosan differentially impacts immune cell populations in the skin of haired (BALB/c) and hairless (SKH1) mice
• Dermal exposure to the immunomodulatory antimicrobial chemical triclosan alters the skin barrier integrity and microbiome in mice

Infectious Diseases

• Masks and ventilation
  • Face mask fit modifications that improve source control performance dataset
  • Constant vs. cyclic flow when testing face masks and respirators as source control devices for simulated respiratory aerosols

• • Efficacy of ventilation, HEPA air cleaners, universal masking, and physical distancing for reducing exposure to simulated exhaled aerosols in a meeting room
  • Efficacy of Do-It-Yourself Air Filtration Units in Reducing Exposure to Simulated Respiratory Aerosols
  • Reduction of exposure to simulated respiratory aerosols using ventilation, physical distancing, and universal masking
  • Efficacy of Portable Air Cleaners and Masking for Reducing Indoor Exposure to Simulated Exhaled SARS-CoV-2 Aerosols — United States, 2021
  • Efficacy of universal masking for source control and personal protection from simulated respiratory aerosols in a room

• Influenza
  • β-defensin-1 regulates influenza virus infection in human bronchial epithelial cells through the STAT3 signaling pathway

• • Effects of antimicrobial chemical exposures on influenza vaccination and antiviral immunity
  • Influenza virus induced novel miRNAs regulate the STAT pathway

Injury

• Economic Burden of Occupational Fatal Injuries in the United States Based on the Census of Fatal Occupational Injuries, 2003-2010
• Evaluation of the fall protection of Type I industrial helmets

Musculoskeletal Disorders

• A model for detecting the effects of vibration on peripheral blood flow
• Video-Based 3D pose estimation for residential roofing-dataset
• Agreement of hip kinematics between two tracking marker configurations used with the 1 CODA pelvis during ergonomic roofing tasks

Noise/Hearing Loss

• NIOSH HHE Program: Noise Measurement Database
• Prevalence of Hearing Loss in the United States by Industry(2013 publication dataset)
• Trends in Worker Hearing Loss by Industry Sector, 1981-2010(2015 publication dataset)

PFAS

• Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model

Reproductive Health

• Effects of Welding Fume Exposure on Human Placental Cells
• Gene expression profiling of di-n-butyl phthalate in normal human mammary epithelial cells

Respiratory Health

• Pulmonary effects
  • Effects of e-cigarette flavoring chemicals on human macrophages and bronchial epithelial cells
  • Biological effects of inhaled crude oil vapor. III. Pulmonary effects
  • Lung Toxicity Profile of Inhaled Copper-Nickel Welding Fume in A/J Mice
  • In vivo and in vitro toxicity of a stainless-steel aerosol generated during thermal spray coating
• Respiratory Protection

• • Respirator performance against nanoparticles under simulated workplace activities data
  • Projectile fluid penetration and flammability of respirators and other head/facial personal protective equipment (FPFPPE)
  • Total Inward Leakage (TIL) for respiratory protective devices

• Pneumoconiosis
  • An investigation into the relationship between coal workers’ pneumoconiosis and dust exposure in U.S. coal miners
  • Prevalence of pneumoconiosis and its relationship to dust exposure in a cohort of U.S. bituminous coal miners and ex-miners

• Exposure systems
  • Automated oil vapor inhalation exposure system
  • Development of a thermal spray coating aerosol generator and inhalation exposure system

Other

• Elevated muscle mass accompanied by transcriptional and nuclear alterations several months following cessation of resistance-type training in rats