Persons Under Investigation

Children with Acute Hepatitis of Unknown Etiology

While rare, children can still have serious hepatitis, and we don’t always know the cause. That’s why investigators continue to look at possible causes and investigate.

Numbers of persons under investigation (PUI): 305

PUI does not mean this person is a confirmed case. The states and CDC are looking broadly (including hepatitis cases of unknown origin in children under 10 years of age, since October, 2021), so this number may go up or down as CDC and states review medical charts and learn more.

States and Jurisdictions Reporting at Least One Person Under Investigation (42)* as of June 22, 2022

*These may not be recent cases of hepatitis being reported.

To protect patient privacy, numbers for each state will not be released.

These data were posted on June 22, 2022 and reflect data from October 1, 2021. Reported PUIs are preliminary and subject to change as more data become available. Data will be updated weekly.

Person Under Investigation: Children <10 years of age with elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) (>500 U/L) who have an unknown etiology for their hepatitis (with or without any adenovirus testing results, independent of the results) since October 1, 2021.

Page last reviewed: June 22, 2022