Past Reported Global Human Cases with Highly Pathogenic Avian Influenza A(H5N1) (HPAI H5N1) by Country, 1997-2022

This graph shows all human infections with HPAI H5N1 bird flu virus reported to the World Health Organizationexternal icon (WHO), since the first human cases in 1997.

H5N1 bird flu viruses first emerged in southern China in 1996. Those viruses caused large poultry outbreaks in Hong Kong in 1997, which resulted in 18 human infections. The 1997 bird outbreak was controlled, but the H5N1 bird flu viruses were not eradicated in birds and re-surfaced in 2003 to spread widely in birds throughout Asia, and later in Africa, Europe, and the Middle East, causing poultry outbreaks and sporadic human infections. Since 2003, 19 countries have reported more than 860 human infections with H5N1 bird flu viruses to WHO.

H5N1 bird flu viruses that are currently circulating in wild birds and poultry in much of the world are genetically different from earlier versions of the virus and emerged to become the predominant subtype of HPAI H5 in the fall of 2021. These viruses have caused sporadic poultry infections and poultry outbreaks in many countries, most recently the United States. In contrast to previous H5N1 viruses, which still circulate to a lesser extent in several countries, at this time, only two human cases with current H5N1 bird flu viruses have been reported.

One infection occurred in December 2021 in a person in the United Kingdom who did not have any symptoms and who raised birds that became infected with H5N1 bird flu viruses.

A second human case was reported in the United States in April 2022 in a person who was involved in culling (depopulating) of H5N1 virus-infected poultry. The person reported fatigue and has recovered.