Association of environmental toxins with amyotrophic lateral sclerosis
Affiliates | Feng-Chiao Su [1], Stephen A. Goutman [2], Sergey Chernyak [1], Bhramar Mukherjee [3], Brian C. Callaghan [2], Stuart Batterman [1], Eva L. Feldman [2,4]
[1] Department of Environmental Health Sciences, University of Michigan |
Journal | JAMA Neurology |
Summary | This study aims to evaluate the association of occupational exposures and environmental toxins on the odds of developing ALS in Michigan. Multivariable models with self-reported occupational exposures in various exposure time windows and environmental toxin blood concentrations were separately fit by logistic regression models. Concordance between the survey data and pollutant measurements was assessed using the nonparametric Kendall τ correlation coefficient. This study found significant associations with several persistent environmental pollutants (measured via blood) and ALS. |
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Page last reviewed: July 14, 2021
Content source: Agency for Toxic Substances and Disease Registry