Current pathways for epidemiological research in amyotrophic lateral sclerosis
Affiliates | Pam Factor-Litvak [1], Ammar Al-Chalabi [2], Alberto Ascherio [3], Walter Bradley [4], Adriano Chio [5], Ralph Garruto [6], Orla Hardiman [7], Freya Kamel [8], Edward Kasarskis [9], Ann McKee [10[, Imaharu Nakano [11], Lorene M. Nelson [12], Andrew Eisen [13]
[1] Department of Epidemiology, Mailman School of Public Health, Columbia University |
Journal | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration |
Summary | This paper reviews findings in ALS research. Descriptions of recent studies and new methods, and a discussion of the pathological similarities between ALS and chronic traumatic encephalomyelopathy (CTE) are discussed. The authors stress the need to address the following concerns: 1) varying definitions for ALS case ascertainment, 2) inconsistences in incidence, prevalence, and lifetime risk of ALS estimates, 3) incidence of ALS within certain subgroups, and 4) the rigor of which ALS etiology is studied. |
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