Reproductive History and Age of Onset for Women Diagnosed with Amyotrophic Lateral Sclerosis: Data from the National ALS Registry: 2010-2018

Affiliates Jaime Raymond [1], Paul Mehta [1], Ted Larson [1], Erik P. Pioro [2], D. Kevin Horton [1]


[1] Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry/Centers for Disease Control and Prevention
[2] Section of ALS and Related Disorders, The Cleveland Clinic

Journal Neuroepidemiology
Summary Estrogen has suspected neuroprotective properties. This investigation seeks to understand how early onset menopause and coinciding drops in estrogen production relay risk of ALS. This examination reported a positive association between receiving an ALS diagnosis before age 60 for women who entered menopause before age 50 when compared to women who reported entering menopause after age 50.
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