Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S.

Affiliates Angeline Andrew [1], Jie Zhou [2], Jiang Gui [2], Antoinette Harrison [3], Xun Shi [2], Meifang Li [2], Bart Guetti [1],  Ramaa Nathan [4], Maeve Tischbein [1], Erik P. Pioro [6], Elijah Stommel [1], Walter Bradley [5]


[1] Dartmouth-Hitchcock Medical Center
[2] Dartmouth College, Hanover
[3] Mitsubishi Tanabe Pharma America, Inc.
[4] Eversana, Wayne
[5] Department of Neurology, Miller School of Medicine, University of Miami
[6] Center for ALS and Related Disorders, Cleveland Clinic

Journal Neurotoxicology
Summary This study investigates the potential of neurotoxic pesticides in the etiology of sporadic amyotrophic lateral sclerosis (ALS). Geospatial estimations of crop-applied pesticides on the county level were estimated and assessed for positive associations to ALS cases. Findings supported a positive association between neurotoxic pesticide exposures and sporadic ALS, and call for focused studies to assess causality.
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