Job-related formaldehyde exposure and ALS mortality in the USA

Affiliates Andrea L Roberts [1], Norman J Johnson [2], Merit E Cudkowicz [3,4], Ki-Do Eum [5], Marc G Weisskopf [5,6]


[1] Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health
[2] United States Census Bureau
[3] Harvard Medical School
[4] Department of Neurology, MGH MDA ALS Clinic, Massachusetts General Hospital
[5] Department of Environmental Health, Harvard T.H. Chan School of Public Health
[6] Department of Epidemiology, Harvard T.H. Chan School of Public Health

Journal Journal of Neurology, Neurosurgery, and Psychiatry
Summary This study examines the association of ALS mortality with job-related formaldehyde exposure in the National Longitudinal Mortality Study (NLMS), a US-representative cohort with occupation data collected prospectively. High probability of formaldehyde exposure versus no exposure predicted an almost three times higher rate of ALS mortality in men. High-probability, high-intensity exposure was associated in men with increased rate of ALS mortality, although there were only two ALS deaths among these highly exposed men.
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