Gene-Environment-Time Interactions in Neurodegenerative Diseases: Hypotheses and Research Approaches

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Affiliates	Walter G. Bradley [1], Angeline S. Andrew [2], Bryan J. Traynor [3,4], Adriano Chiò [5], Tanya H. Butt [2], & Elijah W. Stommel [2] [1] Department of Neurology, Miller School of Medicine, University of Miami [2] Department of Neurology, Geisel School of Medicine at Dartmouth [3] Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health [4] Department of Neurology, Johns Hopkins University [5] ‘‘Rita Levi Montalcini’’ Department of Neuroscience, University of Turin
Journal	Annals of Neurosciences
Summary	This paper proposes a hypothesis to explain the syndrome of ALS based on the interaction of many individual environmental risk factors with many individual genetic predisposing factors. It’s hypothesized that there are many such combinations of individual, specific, genetic, and environmental factors, and that each combination can lead to the development of the syndrome of ALS.
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