Early life metal dysregulation in amyotrophic lateral sclerosis

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Affiliates Claudia Figueroa-Romero [1], Kristen A. Mikhail [1], Chris Gennings [2], Paul Curtin [2], Ghalib A. Bello [2], Tatiana M. Botero [3], Stephen A. Goutman [1], Eva L. Feldman [1], Manish Arora [2], Christine Austin [2]

 

[1] Department of Neurology, University of Michigan
[2] Department of Environmental Medicine and Public Health, and Senator Frank Lautenberg Laboratory for Environmental Health Sciences, Icahn School of Medicine at Mount Sinai
[3] Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry University of Michigan
Journal Annals of Clinical and Translational Neurology
Summary Deficiencies and excess of essential elements and toxic metals are implicated in amyotrophic lateral sclerosis (ALS), but the age when metal dys-regulation appears remains unknown. This study aims to determine whether metal uptake is dysregulated during childhood in individuals eventually diag-nosed with ALS.
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