Pregnancy Mortality Surveillance System
When did CDC start conducting national surveillance of pregnancy-related deaths?
CDC initiated national surveillance of pregnancy-related deaths in 1986 because more clinical information was needed to fill data gaps about causes of maternal death.
How does CDC define pregnancy-related deaths?
For reporting purposes, a pregnancy-related death is defined as the death of a woman while pregnant or within 1 year of pregnancy termination—regardless of the duration or site of the pregnancy—from any cause related to or aggravated by the pregnancy or its management, but not from accidental or incidental causes.
How are the data collected and coded?
Each year, CDC requests the 52 reporting areas (50 states, New York City, and Washington DC) to voluntarily send copies of death certificates for all women who died during pregnancy or within 1 year of pregnancy, and copies of the matching birth or fetal death certificates, if they have the ability to perform such record links. All of the information obtained is summarized, and medically trained epidemiologists determine the cause and time of death related to the pregnancy. Causes of death are coded by using a system established in 1986 by the American College of Obstetricians and Gynecologists and the Centers for Disease Control and Prevention Maternal Mortality Study Group.
How are the data used?
Data are analyzed by CDC scientists. Information about causes of pregnancy-related deaths and risk factors associated with these deaths is released periodically through peer-reviewed literature, CDC’s Morbidity and Mortality Weekly Reports, and the CDC Web site. This information helps clinicians and public health professionals to better understand circumstances surrounding pregnancy-related deaths and to take appropriate actions to prevent them.
How is data confidentiality protected?
Pregnancy mortality surveillance data are protected under 308(d) Assurance of Confidentiality. Because of this Assurance, all data and documents are considered confidential materials and are safeguarded to the greatest extent possible. This Assurance extends to all pregnancy mortality surveillance data obtained from individual states and reporting areas.
What is the pregnancy-related mortality ratio?
The pregnancy-related mortality ratio is an estimate of the number of pregnancy-related deaths for every 100,000 live births. This ratio is often used as an indicator to measure the nation's health. Factors that affect the health of the entire population can also affect mortality among pregnant and postpartum women.
The pregnancy-related mortality ratio fell significantly in the United States during the 20th century. This historic decline was because of medical and technological advances. Interest and concern at the local, state, and federal levels for why pregnancy-related deaths occur led to the development of systems for identifying, reviewing, and analyzing pregnancy-related deaths.
Since the Pregnancy Mortality Surveillance System was implemented, the number of reported pregnancy-related deaths in the United States steadily increased from 7.2 deaths per 100,000 live births in 1987 to a high of 17.8 deaths per 100,000 live births in 2009. The graph below shows trends in pregnancy-related mortality ratios defined as the number of pregnancy-related deaths per 100,000 live births in the United States between 1987 and 2010 (the latest available year of data).
Trends in pregnancy-related mortality in the United States: 1987–2010
The reasons for the overall increase in pregnancy-related mortality are unclear. The use of computerized data linkages by the states, changes in the way causes of death are coded, and the addition of a pregnancy checkbox to the death certificate in many states have likely improved identifying pregnancy-related deaths over time. Whether the actual risk of a woman dying from pregnancy-related causes has increased is unclear. Many studies show that an increasing number of pregnant women in the United States have chronic health conditions such as hypertension,1 diabetes,2 and chronic heart disease.3 These conditions may put a pregnant woman at higher risk of adverse outcomes. The higher pregnancy-related mortality ratios in 2009 and 2010 compared to previous years are due to the 2009 H1N1 influenza pandemic which disproportionately affected pregnant women,4 -5 a large number of pregnant women died due to influenza infection especially in 2009.6 Although the overall risk of dying from pregnancy complications is low, some women are at a higher risk than others. Variability in the risk of death by race, ethnicity, and age indicates that more can be done to understand and reduce pregnancy-related deaths.7
Causes of and risk factors for pregnancy-related deaths between 1987 and 2005 have already been published in the literature.8-10 Key pregnancy-related mortality data for 2006–2010 (the latest data available) are summarized below.
In the United States
Of the 8,386 deaths within a year of pregnancy termination that occurred between 2006 and 2010 and were reported to CDC, 3,358 were found to be pregnancy-related. The pregnancy-related mortality ratio was 16 deaths per 100,000 live births for the period 2006–2010.
Considerable racial disparities in pregnancy-related mortality exist. During the 2006–2010 period, the pregnancy-related mortality ratios were
- 11.7 deaths per 100,000 live births for white women.
- 36.4 deaths per 100,000 live births for black women.
- 17.7 deaths per 100,000 live births for women of other races.
The graph below shows percentages of pregnancy-related deaths in the United States between 2006–2010 caused by
- Cardiovascular diseases, 14.6%.
- Infection or sepsis, 13.6%.
- Non-cardiovascular diseases, 12.7%.
- Cardiomyopathy, 11.8%.
- Hemorrhage, 11.4%.
- Thrombotic pulmonary embolism, 9.6%.
- Hypertensive disorders of pregnancy, 9.4%.
- Cerebrovascular accidents, 6.2%.
- Amniotic fluid embolism, 5.3%.
- Anesthesia complications, 0.7%.
The cause of death is unknown for 4.7% of all 2006–2010 pregnancy-related deaths.
Causes of pregnancy-related death in the United States: 2006–2010
- Hypertensive disorders and severe obstetric morbidity in the United States: 1998–2006.Obstet Gynecol. 2009;113(6):1299–1306.
- Diabetes trends among delivery hospitalizations in the United States, 1994–2004.Diabetes Care. 2010;33(4):768–773.
- Chronic heart disease and severe obstetric morbidity among hospitalizations for pregnancy in the USA: 1995–2006. Br J Obstet Gynaecol. 2011;118(3):345–352.
- Severity of 2009 pandemic influenza A (H1N1) virus infection in pregnant women. Obstet Gynecol. 2010;115(4):717–726.
- Severe 2009 H1N1 influenza in pregnant and postpartum women in California. N Engl J Med. 2010;;362(1):27–35.
- Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States. JAMA. 2010; 21;303(15):1517–1525.
- Race, ethnicity and nativity differentials in pregnancy-related mortality in the United States: 1993–2006. Obstet Gynecol. 2012;120(2):261–268.
- Pregnancy-related mortality in the United States, 1987–1990. Obstet Gynecol.1996;88:161–167.
- Pregnancy-related mortality in the United States, 1991–1997. Obstet Gynecol.2003;101:289–296.
- Pregnancy-related mortality in the United States, 1998–2005. Obstet Gynecol.2010;116:1302–1309.