Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

The content, links, and pdfs are no longer maintained and might be outdated.

  • The content on this page is being archived for historic and reference purposes only.
  • For current, updated information see the MMWR website.

Notes from the Field: Hantavirus Pulmonary Syndrome in Visitors to a National Park — Yosemite Valley, California, 2012

On August 16, 2012, the California Department of Public Health announced two confirmed cases of hantavirus pulmonary syndrome (HPS) in California residents who had stayed overnight in Yosemite National Park, launching an investigation by the National Park Service, California Department of Public Health, and CDC. On August 27, Yosemite National Park announced two additional cases, and by October 30, 10 cases had been confirmed.

For this outbreak, a confirmed case was defined as detection of 1) a febrile illness and hantavirus (Sin Nombre virus) specific antibodies in serum, or 2) virus antigen in postmortem tissue using immunohistochemistry, in a person who had stayed overnight in Yosemite National Park during June 1–August 28, 2012. CDC notified public health officials and clinical providers in the United States and internationally. The National Park Service notified by e-mail, telephone, or mail all registered overnight Yosemite National Park visitors (approximately 260,000 guests) who had stayed at the park during June 1–September 17, 2012.

The 10 confirmed patients came from three states: California (eight), West Virginia (one), and Pennsylvania (one). Ages ranged from 12 years to 56 years; four were female. Nine patients had typical symptoms of HPS, and one lacked respiratory symptoms; three died.

Nine patients stayed in Curry Village "signature" cabins, which have insulation between the canvas exterior and interior hard walls. Rodent infestations were detected in the insulation, and all 91 signature cabins were closed indefinitely on August 28. In addition, educational interventions were enhanced for staff members and visitors parkwide, and multifaceted rodent control measures, including trapping throughout Curry Village, were implemented.

HPS is a nationally notifiable disease caused in the United States most commonly by Sin Nombre virus. The deer mouse (Peromyscus maniculatus) is the reservoir. Infected mice shed virus in urine, feces, and saliva. Humans become infected through inhalation of aerosolized virus from rodent excreta and via direct contact from rodent bites. The incubation period ranges from 1 to 6 weeks. Early symptoms include fever, chills, myalgia, headache, and gastrointestinal symptoms for 1–7 days, progressing rapidly to respiratory distress and shock (1). Most patients require hospitalization, supplemental oxygen, and intubation. The case-fatality rate is approximately 36% (2). There is no specific treatment for HPS, but early supportive care can reduce mortality (2). Before this outbreak, 58 cases of HPS had been reported among California residents since 1994; two had been visitors to Yosemite National Park before 2012 (California Department of Public Health, unpublished data, 2012).

Clinicians are reminded to consider the diagnosis of hantavirus infection in all persons with febrile illness and sudden onset of respiratory symptoms with a history of rodent exposure. Because HPS is a reportable disease in the United States, clinicians suspecting HPS should notify and consult their state health department about confirmatory testing. More information is available from CDC regarding hantavirus clinical assessment, treatment and diagnostics (3). Park visitors and the public are advised to avoid contact with rodents and their urine, droppings, and nesting materials.

Reported by

California Dept of Public Health, Div of Communicable Disease Control. Pennsylvania State Health Dept. West Virginia Bur for Public Health. Office of Public Health, National Park Svc. Viral Special Pathogens Br, National Center for Emerging and Zoonotic Infectious Diseases, CDC. Corresponding contributor: Lynda U. Osadebe, ckv2@cdc.gov. 404-718-4823.

References

  1. CDC. Hantavirus pulmonary syndrome—United States: updated recommendations for risk reduction. MMWR 2002;51(No. RR-9).
  2. MacNeil A, Ksiazek TG, Rollin PE. Hantavirus pulmonary syndrome, United States, 1993–2009. Emerg Infect Dis 2011;17:1195–201.
  3. CDC. Hantavirus. Atlanta, GA: US Department of Health and Human Services, CDC; 2012. Available at http://www.cdc.gov/hantavirus. Accessed November 14, 2012.

Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services.

References to non-CDC sites on the Internet are provided as a service to MMWR readers and do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. CDC is not responsible for the content of pages found at these sites. URL addresses listed in MMWR were current as of the date of publication.


All MMWR HTML versions of articles are electronic conversions from typeset documents. This conversion might result in character translation or format errors in the HTML version. Users are referred to the electronic PDF version (http://www.cdc.gov/mmwr) and/or the original MMWR paper copy for printable versions of official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices.

**Questions or messages regarding errors in formatting should be addressed to mmwrq@cdc.gov.

 
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #