Public Health Genomics Program Review
4.0 Scientific Highlights in FY2007
This section provides a summary of OPHG’s major scientific highlights in FY2007. References to scientific publications by OPHG are provided.
4.1 Evaluation of Genomic Applications in Practice and Prevention (EGAPP™)
EGAPP™ activities are focused around the independent, non-federal EGAPP™ Working Group established in May 2005. The roles of this multidisciplinary panel include optimization of methods and processes for evidence review to deal with complex and rapidly emerging technologies; identification, prioritization and selection of topics; participation on technical expert panels that guide conduct of evidence reports; and development of recommendation statements for clinicians based on the evidence.
In FY2007, four CDC-funded evidence reports were completed for the EGAPP™ Working Group by Evidence-Based Practice Centers (EPCs), through an interagency agreement with the Agency for Healthcare Research and Quality (AHRQ):
- Genomic Tests for Ovarian Cancer Detection and Management
- Testing for Cytochrome P450 (CYP450) Polymorphisms in Adults With Non-Psychotic Depression Treated With Selective Serotonin Reuptake Inhibitors (SSRIs)
- Hereditary Nonpolyposis Colorectal Cancer: Diagnostic Strategies and Their Implications
- Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes
Another non-EPC report, Can UGT1A1 Genotyping Reduce Morbidity and Mortality in Patients with Metastatic Colorectal Cancer Treated with Irinotecan?, and a supplemental report, DNA Testing Strategies Aimed at Reducing Morbidity and Mortality from Lynch Syndrome, will be released in early 2008.
Based on consideration of the availability and quality of evidence and clinical and social contextual issues, the Working Group develops recommendation statements that summarize current knowledge, provides guidance on appropriate use, and defines key gaps and needed research. In FY2007, the first in a series of EGAPP™ Working Group recommendation statements, on CYP450 testing in patients with depression treated with SSRIs, was accepted for publication in Genetics in Medicine (December 2007 issue).
Other EGAPP™ accomplishments for FY2007 include the establishment, with OPHG support, of the EGAPP™ Stakeholders Group, and the independent Web site (http://www.egappreviews.org), which hosts products of the EGAPP™ Working Group.