Available Isolates and Antimicrobial Susceptibility Testing
Isolate Request Process
CDC isolate bank custodians review requests for isolates prior to approval and release.
Please contact us for the current price per isolate, which applies to for-profit institutions only. All requestors are required to pay shipping fees.
View more information on the isolate bank request process.
Isolates available as of July 3, 2023
Isolates are available between 1995–2021 with certain demographic and clinical data and laboratory testing results.
Group A Streptococcus
Age groups: < 1 year, 1 year, 2–4 years, 5–17 years, 18–34 years, 35–49 years, 50–64 years, ≥ 65 years
Infection type/syndrome:
- Cellulitis
- Bacteremia without focus
- Pneumonia
- Necrotizing fasciitis
- Streptococcal toxic shock syndrome
- Other infection type/syndrome
Source:
- Cerebrospinal fluid
- Blood
- Other sterile site
Laboratory testing results:
- emm type
- Presence or absence of serum opacity factor
- Minimum inhibitory concentration for select antibiotics (see table below)
Group B Streptococcus
Age groups: < 1 year, 1 year, 2–4 years, 5–17 years, 18–34 years, 35–49 years, 50–64 years, ≥ 65 years
Additional age groupings available for young infant cases <90 days old:
- Early-onset disease (0–6 days)
- Late-onset disease (7–89 days)
Infection type/syndrome:
- Bacteremia without focus
- Meningitis
- Pneumonia
- Other infection type/syndrome
Source:
- Cerebrospinal fluid
- Blood
- Other sterile site
Laboratory testing results:
- Serotype
- Minimum inhibitory concentration for select antibiotics (see table below)
Haemophilus influenzae
Age groups: < 1 year, 1 year, 2–4 years, 5–17 years, 18–34 years, 35–49 years, 50–64 years, ≥ 65 years
Infection type/syndrome:
- Bacteremia without focus
- Meningitis
- Pneumonia
- Other infection type/syndrome
Source:
- Cerebrospinal fluid
- Blood
- Other sterile site
Laboratory testing result: Serotype
Neisseria meningitidis
Age groups: < 1 year, 1 year, 2–4 years, 5–17 years, 18–34 years, 35–49 years, 50–64 years, ≥ 65 years
Infection type/syndrome:
- Bacteremia without focus
- Meningitis
- Other infection type/syndrome
Source:
- Cerebrospinal fluid
- Blood
- Other sterile site
Laboratory testing results: Serogroup
Streptococcus pneumoniae
Age groups: < 1 year, 1 year, 2–4 years, 5–17 years, 18–34 years, 35–49 years, 50–64 years, ≥ 65 years
Infection type/syndrome:
- Bacteremia without focus
- Meningitis
- Pneumonia
- Other infection type/syndrome
Source:
- Cerebrospinal fluid
- Blood
- Other sterile site
Laboratory testing results:
- Serotype
- Minimum inhibitory concentration for select antibiotics (see table below)
Isolate antimicrobial susceptibility testing
Minimum inhibitory concentration (MIC) of antibiotics are
- Determined by phenotypic antimicrobial susceptibility testing (AST)
- Inferred from whole-genome sequencing (WGS)
MIC results were determined
- Prior to 2015: Solely on AST results from phenotypic testing
- In 2015: Using both phenotypic- and WGS-based methods
- From 2016 through present: Primarily inferred from WGS (conventional MIC testing is performed on selected isolates)
Antibiotic | Group A Streptococcus | Group B Streptococcus | Streptococcus pneumoniae |
---|---|---|---|
Amoxicillin | 3 | 3 | 2 |
Ampicillin | 2 | 2 | 3 |
Cefazolin | 2* | 2* | 3 |
Cefotaxime | 1 | 1 | 1 |
Cefoxitin | 2* | 2* | 3 |
Ceftizoxime | 2* | 2* | 3 |
Ceftriaxone | 2 | 2 | 2 |
Cefuroxime | 3 | 3 | 2 |
Chloramphenicol | 2 | 2 | 2 |
Clindamycin | 1 | 1 | 2 |
Doxycycline | 3 | 3 | 2 |
Dtest: ERY/CM | 2 | 2 | 2 |
Erythromycin | 1 | 1 | 1 |
Levofloxacin | 2 | 2 | 1 |
Linezolid | 2 | 2 | 2 |
Meropenem | 2 | 2 | 2 |
Penicillin | 1 | 1 | 1 |
Rifampin | 2* | 2* | 2 |
Synercid | 2 | 2 | 2 |
Tetracycline | 1 | 2 | 1 |
Trimethoprim/Sulfamethoxasole | 2* | 2* | 1 |
Vancomycin | 1 | 1 | 1 |
1 | Results are aggregated and publicly available in BactFacts Interactive and/or surveillance reports |
2 | Results are not routinely reported to the public |
2* | Results don’t have Clinical and Laboratory Standards Institute (CLSI) breakpoints |
3 | Not routinely tested for the pathogen |