Examples of Major or "Take" Reactions to Smallpox Vaccination

Formation of a papule, vesicle, ulcer, or crusted central lesion by days 6 to 8 after vaccination signifies a response to vaccination; this event is referred to as a major reaction or a “take,” and usually results in a scar.

Normal primary, 8 days post vaccination. Large vesicle on erythematous base. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Large vesicle on erythematous base. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Minimal surrounding erythema at 8 days. Source: NIH, digital enhancement © Logical Images.

Norml primary, 8 days post vaccination. Minimal surrounding erythema at 8 days. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Grayish pustule, with difficult to detect surrounding erythema in dark skin. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Grayish pustule, with difficult to detect surrounding erythema in dark skin. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Grayish colored pustule with minimal detectable erythema in this very dark skin type. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Small vesicle with minimal erythema at 8 days post vaccination. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Small vesicle with minimal erythema at 8 days post vaccination. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. Bi-lobed normal pustule with minimal surrounding erythema at 8 days post vaccination. Source: NIH, digital enhancement © Logical Images.

Normal primary, 8 days post vaccination. “Bi-lobed” normal pustule with minimal surrounding erythema at 8 days post vaccination. Source: NIH, digital enhancement © Logical Images.