Comparison of Reactions for First-Time Vaccinees and Revaccinees

This information is about preventing or responding to smallpox. For the latest information about the current mpox outbreak, including information on symptoms, prevention, and vaccines, please visit CDC’s Mpox site.

Image Set 1 | Image Set 2

Vaccination sites sometimes resolve more rapidly in revaccinees. The images below compare reactions between primary vaccinees and revaccinees.

Note: Not all vaccine reactions photos are available for each day listed below.

Image Set 1

Day 6—First-Time Vaccinee

Vaccine %26ldquo;take%26rdquo; on day 6 after vaccination in a first-time vaccinee.

Vaccine “take” on day 6 after vaccination in a first-time vaccinee.

Day 6—Revaccinee

No image available for this day

Day 8—First-Time Vaccinee

No image available for this day

Day 8—Revaccinees

Example of a %26ldquo;take%26rdquo; on day 8 after vaccination in a revaccinee.

Example of a “take” on day 8 after vaccination in a revaccinee.

Day 10—First-Time Vaccinee

Example of vaccine %26ldquo;take%26rdquo; on day 10 after vaccination in a first-time vaccinee.

Example of vaccine “take” on day 10 after vaccination in a first-time vaccinee.

Day 10—Revaccinee

Example of a %26ldquo;take%26rdquo; on day 10 after vaccination in a revaccinee.

Example of a “take” on day 10 after vaccination in a revaccinee.

Day 15—First-Time Vaccinee

Example of vaccine “take” on day 15 after vaccination in a first-time vaccinee.

Day 15—Revaccinee

Example of vaccine %26ldquo;take%26rdquo; on day 15 after vaccination in a revaccinee.

Example of vaccine “take” on day 15 after vaccination in a revaccinee.

Source: Vaccination reactions in vaccinia-naïve and previously vaccinated volunteers in a clinical study of diluted Dryvax smallpox vaccine enrolled at the NIAID-supported Vaccine Treatment and Evaluation Units at Saint Louis University in 2002.

Image Set 2

Day 3—First-Time Vaccinee

Vaccination site 3 days after vaccination in first-time vaccinee.

Day 3—Revaccinee Image 1

Vaccination site 3 days after vaccination in revaccinee.

Day 3—Revaccinee Image 2

Vaccination site 3 days after vaccination in another revaccinee.

Day 7—First-Time Vaccinee

Vaccination site 7 days after vaccination in first-time vaccinee.

Day 7—Revaccinee Image 1

Vaccination site 7 days after vaccination in revaccinee.

Day 7—Revaccinee Image 2

Vaccination site 7 days after vaccination in another revaccinee.

Day 10—First-Time Vaccinee

Vaccination site 10 days after vaccination in first-time vaccinee.

Day 10—Revaccinee Image 1

Vaccination site 10 days after vaccination in revaccinee.

Day 10—Revaccinee Image 2

Vaccination site 10 days after vaccination in another revaccinee.

Day 14—First-Time Vaccinee

Vaccination site 14 days after vaccination in first-time vaccinee.

Day 14—Revaccinee Image 1

Vaccination site 14 days after vaccination in revaccinee.

Day 14—Revaccinee Image 2

No image available for this day

Day 18—First-Time Vaccinee

Vaccination site 18 days after vaccination in first-time vaccinee.

Day 18—Revaccinee Image 1

No image available for this day

Day 18—Revaccinee Image 2

No image available for this day

Source: Vaccination reactions in vaccinia-naïve and previously vaccinated volunteers at CDC, 2009.