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Biology - Life Cycle of Brugia malayi

The typical vector for Brugia malayi filariasis are mosquito species from the genera Mansonia and Aedes. During a blood meal, an infected mosquito introduces third-stage filarial larvae onto the skin of the human host, where they penetrate into the bite wound The number 1 . They develop into adults that commonly reside in the lymphatics The number 2 . The adult worms resemble those of Wuchereria bancrofti but are smaller. Female worms measure 43 to 55 mm in length by 130 to 170 μm in width, and males measure 13 to 23 mm in length by 70 to 80 μm in width. Adults produce microfilariae, measuring 177 to 230 μm in length and 5 to 7 μm in width, which are sheathed and have nocturnal periodicity. The microfilariae migrate into lymph and enter the blood stream reaching the peripheral blood The number 3 . A mosquito ingests the microfilariae during a blood meal The number 4 . After ingestion, the microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the midgut to reach the thoracic muscles The number 5 . There the microfilariae develop into first-stage larvae The number 6 and subsequently into third-stage larvae The number 7 . The third-stage larvae migrate through the hemocoel to the mosquito’s prosbocis The number 8 and can infect another human when the mosquito takes a blood meal The number 1 .