Cresol (o, m, p isomers)
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS numbers: 95487 (oisomer), 108394 (misomer), 106445 (pisomer)
NIOSH REL: 2.3 ppm (10 mg/m3) TWA
Current OSHA PEL: 5 ppm (22 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
19931994 ACGIH TLV: 5 ppm (22 mg/m3) TWA [skin]
Description of Substance: White crystals with a sweet, tarry odor.
LEL(@300 F): 1.4% (10% LEL(@300 F), 1,400 ppm)
Original (SCP) IDLH: 250 ppm
Basis for original (SCP) IDLH: The only quantitative acute inhalation toxicity data available are those cited by Patty . Patty  reported that rats exposed for 8 hours to a saturated concentration of cresol vapors survived the exposure [Smyth 1956]. The chosen IDLH is based on the isomer with the highest vapor pressure, that of ocresol, which yields a saturated concentration of 323 ppm at 25 C. The chosen IDLH appears to be conservative because no rats died as a result of this exposure which was for 8 hours. Based on the rat oral LD50 of 207 mg/kg for pcresol [Biofax 1969 cited by NIOSH 1976], an IDLH of 250 ppm is reasonable.
Shortterm exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
Other animal data: Rats exposed to a saturated concentration of cresol vapors (about 150 to 380 ppm) survived the exposure for 8 hours [Smyth 1956].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 250 ppm [Unchanged]Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Smyth 1956], the original IDLH for cresol (250 ppm) is not being revised at this time.|
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2. Biofax [1969a]. Data sheet 35/69. Northbrook, IL: Biofax Industrial BioTest Laboratories, Inc.
3. Biofax [1969b]. Data sheet 45/69. Northbrook, IL: Biofax Industrial BioTest Laboratories, Inc.
4. Biofax [1969c]. Data sheet 55/69. Northbrook, IL: Biofax Industrial BioTest Laboratories, Inc.
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8. NIOSH . GO64750. pCresol. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76191, p. 353.
9. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1390.
10. Smyth HF Jr . Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129185.
- Page last reviewed: December 4, 2014
- Page last updated: December 4, 2014
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