Cresol (o, m, p isomers)
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS numbers: 95487 (oisomer), 108394 (misomer), 106445 (pisomer)
NIOSH REL: 2.3 ppm (10 mg/m3) TWA
Current OSHA PEL: 5 ppm (22 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
19931994 ACGIH TLV: 5 ppm (22 mg/m3) TWA [skin]
Description of Substance: White crystals with a sweet, tarry odor.
LEL(@300 F): 1.4% (10% LEL(@300 F), 1,400 ppm)
Original (SCP) IDLH: 250 ppm
Basis for original (SCP) IDLH: The only quantitative acute inhalation toxicity data available are those cited by Patty . Patty  reported that rats exposed for 8 hours to a saturated concentration of cresol vapors survived the exposure [Smyth 1956]. The chosen IDLH is based on the isomer with the highest vapor pressure, that of ocresol, which yields a saturated concentration of 323 ppm at 25 C. The chosen IDLH appears to be conservative because no rats died as a result of this exposure which was for 8 hours. Based on the rat oral LD50 of 207 mg/kg for pcresol [Biofax 1969 cited by NIOSH 1976], an IDLH of 250 ppm is reasonable.
Shortterm exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
Other animal data: Rats exposed to a saturated concentration of cresol vapors (about 150 to 380 ppm) survived the exposure for 8 hours [Smyth 1956].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 250 ppm [Unchanged]Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Smyth 1956], the original IDLH for cresol (250 ppm) is not being revised at this time.|
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2. Biofax [1969a]. Data sheet 35/69. Northbrook, IL: Biofax Industrial BioTest Laboratories, Inc.
3. Biofax [1969b]. Data sheet 45/69. Northbrook, IL: Biofax Industrial BioTest Laboratories, Inc.
4. Biofax [1969c]. Data sheet 55/69. Northbrook, IL: Biofax Industrial BioTest Laboratories, Inc.
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