Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 79–00–5
NIOSH REL: 10 ppm (45 mg/m3) TWA [skin]; NIOSH considers 1,1,2-trichloroethane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 10 ppm (45 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 10 ppm (55 mg/m3) TWA [skin]
Description of substance: Colorless liquid with a sweet, chloroform-like odor.
LEL: . . 6% (10% LEL, 6,000 ppm)
Original (SCP) IDLH: 500 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC  report that 500 ppm killed 1 of 6 rats in 4 hours, and 4 of 6 rats in 8 hours.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50||LCLo||Time||Adjusted 0.5-hrLC (CF)||Derived value|
|Cat||Arch Hyg Bakteriol 1936||—–||13,100 mg/m3||4.5 hr||4,957 ppm (2.1)||496 ppm|
|Rat||Carpenter et al. 1949||—–||2,000 ppm||4 hr||4,000 ppm (2.0)||400 ppm|
|Rat||UCC 1972||LC17: 500 ppm||—–||4 hr||1,000 ppm (2.0)||100 ppm|
|Rat||UCC 1972||LC67: 500 ppm||—–||8 hr||1,250 ppm (2.5)||125 ppm|
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 100 ppmBasis for revised IDLH: The revised IDLH for 1,1,2-trichloroethane is 100 ppm based on acute inhalation toxicity data in animals [UCC 1972]. [Note: NIOSH recommends as part of its carcinogen policy that the “most protective” respirators be worn for 1,1,2-trichloroethane at concentrations above 10 ppm.]|
1. Arch Hyg Bakteriol ; 116:131 (in German).
2. Carpenter CP, Smyth HF Jr, Pozzani UC . The assay of acute vapor toxicity and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol 31(6):343-346.
3. UCC . Toxicology studies: 1,1,2-trichloroethane. New York, NY: Union Carbide Corporation.
- Page last reviewed: December 4, 2014
- Page last updated: December 4, 2014
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