Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 7786–34–7
NIOSH REL: 0.01 ppm (0.1 mg/m3) TWA, 0.03 ppm (0.3 mg/m3) STEL [skin]
Current OSHA PEL: 0.1 mg/m3 TWA [skin]
1989 OSHA PEL: 0.01 ppm (0.1 mg/m3) TWA, 0.03 ppm (0.3 mg/m3) STEL [skin]
1993-1994 ACGIH TLV: 0.01 ppm (0.92 mg/m3) TWA,
0.03 ppm (0.27 mg/m3) STEL [skin]
Description of substance: Pale-yellow to orange liquid with a weak odor.
LEL: . . Unknown
Original (SCP) IDLH: 4 ppm
Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for Phosdrin. The chosen IDLH has been estimated from the male rat oral LD50 of 6 to 7 mg/kg [Shell 1956 cited by ACGIH 1971]. [Note: A concentration of 4 ppm phosdrin is equivalent to about 40 mg/m3.]
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50 (ppm)||LCLo (ppm)||Time||Adjusted 0.5-hr LC (CF)||Derived value|
|Rat||Kodama et al. 1954||14||-----||1 hr||18 ppm (1.25)||1.8 ppm|
Lethal dose data:
|Species||Reference||Route||LD50 (mg/kg)||LDLo (mg/kg)||Adjusted LD||Derived value|
Kodama et al. 1954
Human data: A dose of 2.5 mg/day for 27 days caused a 25% decrease in red blood cell cholinesterase [Rider et al. 1975]. [Note: An oral dose of 2.5 mg/day for 27 days is equivalent to a worker being exposed to about 5 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
|Revised IDLH: 4 ppm [Unchanged]
Basis for revised IDLH: Based on acute toxicity data in humans [Rider et al. 1975], the original IDLH for phosdrin (4 ppm) is not being revised at this time.
1. ACGIH . Phosdrin (mevinphos). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 208.
2. Kenaga EE . Acute and chronic toxicity of 75 pesticides to various animal species. Down to Earth 35:25-31.
3. Kodama J, Morse MS, Anderson HH, Dunlap MK, Hines CH . Comparative toxicity of two vinyl-substituted phosphates. AMA Arch Ind Hyg Occup Med 9:45-61.
4. Rider JA, Puletti EJ, Swader JI . The minimal oral toxicity level for mevinphos in man. Toxicol Appl Pharmacol 32(10):97-100.
5. Shell . Personal communication to ACGIH from the Shell Chemical Corporation, August 31, 1956. [From ACGIH . Phosdrin. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1044-1046.]