n-Propyl nitrate

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number 627-13-4

NIOSH REL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL

Current OSHA PEL 25 ppm (110 mg/m3) TWA

1989 OSHA PEL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL

1993-1994 ACGIH TLV 25 ppm (107 mg/m3) TWA, 40 ppm (172 mg/m3) STEL

Description of substance Colorless to straw-colored liquid with an ether-like odor.

LEL . . 2% (10% LEL, 2,000 ppm)

Original (SCP) IDLH 2,000 ppm

Basis for original (SCP) IDLH The chosen IDLH is based on the statement by ACGIH [1971] that the dog 4-hour LC50 is 2,000 to 2,500 ppm [Rinehart et al. 1958].

Short-term exposure guidelines None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derived value
Rat Hood 1953 —– 10,000 4 hr 20,000 ppm (2.0) 2,000 ppm
Rat Rinehart et al Mouse. 1958 —– 9,000 – 10,000 4 hr 18,000-20,000 ppm (2.0) 1,800-2,000 ppm
Mouse Rinehart et al. 1958 —– 6,000 – 7,000 4 hr 12,000-14,000 ppm (2.0) 1,200-1,400 ppm
Dog Rinehart et al. 1958 —– 2,000 – 2,500 4 hr 4,000- 5,000 ppm (2.0) 400- 500 ppm

Human data None relevant for use in determining the revised IDLH.

REFERENCES:

1. ACGIH [1971]. n-Propyl nitrate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 217-218.

2. Hood DB [1953]. Toxicity of n-propyl nitrate and isopropyl nitrate. Report No. 21-53, Medical Research Project No. MR-170. Newark, DE: E.I. du Pont de Nemours & Co., Inc., Haskell Laboratory for Toxicology and Industrial Medicine.

3. Rinehart WE, Garbers RC, Greene EA, Stoufer RM [1958]. Studies on the toxicity of n-propyl nitrate vapor. Am Ind Hyg Assoc J 19:80-83.

Page last reviewed: December 4, 2014