Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 556–52–5
NIOSH REL: 25 ppm (75 mg/m3) TWA
Current OSHA PEL: 50 ppm (150 mg/m3) TWA
1989 OSHA PEL: 25 ppm (75 mg/m3) TWA
1993-1994 ACGIH TLV: 25 ppm (76 mg/m3) TWA
Description of Substance: Colorless liquid.
LEL: . . Unknown
Original (SCP) IDLH: 500 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 450 ppm and the rat 8-hour LC50 of 580 ppm [Hine et al. 1956 cited by ACGIH 1971, and Patty 1963].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derivedvalue|
|MouseRat||Hine et al. 1956Hine et al. 1956||450580||———-||4 hr8 hr||900 ppm (2.0)1,450 ppm (2.5)||90 ppm145 ppm|
Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 150 ppmBasis for revised IDLH: The revised IDLH for glycidol is 150 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956].|
1. ACGIH . Glycidol. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 121-122.
2. Hine CH, Kodama JS, Wellington JS, Dunlap MK, Anderson HH . The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
3. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1635.