Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 124–40–3
NIOSH REL: 10 ppm (18 mg/m3) TWA
Current OSHA PEL: 10 ppm (18 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (9.2 mg/m3) TWA, 15 ppm (27.6 mg/m3) STEL
Description of Substance: Colorless gas with an ammonia- or fish-like odor.
LEL:. . 2.8% (10% LEL, 2,800 ppm)
Original (SCP) IDLH: 2,000 ppm
Basis for original (SCP) IDLH: No data on acute inhalation toxicity are available for dimethylamine. Therefore, the chosen IDLH is based on an analogy with diethylamine which has an IDLH of 2,000 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derivedvalue|
|Koch et al. 1980Steinhagen et al. 1982
Steinhagen et al. 1982
|4 hr6 hr
|9,400 ppm (2.0)10,442 ppm (2.3)
12,240 ppm (1.6)
|940 ppm1,044 ppm
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Dzhanashvili 1967Dzhanashvili 1967
|2,613 ppm1,183 ppm
|261 ppm118 ppm
Other animal data: RD50 (mouse), 511 ppm [Steinhagen et al. 1982]; RD50 (rat), 573 ppm [Steinhagen et al. 1982].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for dimethylamine is 500 ppm based on acute inhalation toxicity data in animals [Steinhagen et al. 1982].|
1. Dzhanashvili GD . Maximum permissible concentration of dimethylamine in water bodies. Gig Sanit 32(6):329-335 (translated).
2. Koch F, Guenter M, Kliche R, Lang R . Studies on the aerogenic intoxication of rats by means of methylamines. Wiss Z: Karl Marx University, Leipzig, Math-Naturwiss. Reihe 29:463-474. [From ACGIH . Dimethylamine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 479-481.]
3. Steinhagen WH, Swenberg JA, Barrow CS . Acute inhalation toxicity and sensory irritation of dimethylamine. Am Ind Hyg Assoc J 43(6):411-417.
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- Page last updated: December 4, 2014
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