n-Propyl acetate

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 109–60–4

NIOSH REL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

Current OSHA PEL: 200 ppm (840 mg/m3) TWA

1989 OSHA PEL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

1993-1994 ACGIH TLV: 200 ppm (835 mg/m3) TWA, 250 ppm (1,040 mg/m3) STEL

Description of substance: Colorless liquid with a mild, fruity odor.

LEL(@100°F): 1.7% (10% LEL(@100°F), 1,700 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4-hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derived value
Cat Flury & Wirth 1933 —– 8,941 5 hr 19,223 ppm (2.15) 1,922 ppm
Rat Smyth et al. 1969 LC67: 8,000 —– 4 hr 16,000 ppm (2.0) 1,600 ppm

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
RatMouse

Rabbit

Rat

Jenner et al. 1964Jenner et al. 1964

Munch 1972

Smyth et al. 1969

oraloral

oral

oral

9,3708,300

6,640

8,700

———-

—–

—–

15,433 ppm13,671 ppm

10,936 ppm

14,329 ppm

1,543 ppm1,367 ppm

1,094 ppm

1,433 ppm

Other animal data: It has been reported that based on acute inhalation studies, n-propyl acetate appears to be more toxic than isopropyl acetate and ethyl acetate but less toxic than n-butyl acetate [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.

REFERENCES:

1. ACGIH [1971]. n-Propyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 216.

2. ACGIH [1991]. n-Propyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 1300.

3. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel. (Verschieden ester, aceton, methylalkohol.) Arch Gewerbepath Gewerbehyg 5:1-90 (in German).

4. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG [1964]. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet Toxicol 2:327-343.

5. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg 41:31-33.

6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

7. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS [1969]. Range-finding toxicity data: list VII. Am Ind Hyg Assoc J 30(5):470-476.

Page last reviewed: December 4, 2014