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Allyl chloride

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 107-05-1

NIOSH REL: 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL

Current OSHA PEL: 1 ppm (3 mg/m3) TWA

1989 OSHA PEL: 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL

1993-1994 ACGIH TLV: 1 ppm (3 mg/m3) TWA, 2 ppm (6 mg/m3) STEL

Description of substance: Colorless, brown, yellow, or purple liquid with a pungent, unpleasant odor.

LEL: 2.9% (10% LEL, 2,900 ppm)

Original (SCP) IDLH: 300 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that a 1-hour exposure to 300 ppm might cause serious effects.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Adjusted
LC50 LCLo 0.5-hr Derived
Species Reference (ppm) (ppm) Time LC (CF) Value
Rat Boqin et al. 1982 11,000 mg/m3 —– 2 hr 4,323 ppm (1.25) 434 ppm
Mouse Boqin et al. 1982 11,500 mg/m3 —– 2 hr 4,520 ppm (1.25) 452 ppm
G. pig Boqin et al. 1982 5,800 mg/m3 —– 2 hr 2,280 ppm (1.25) 228 ppm
Rabbit Boqin et al. 1982 22,500 mg/m3 —– 2 hr 8,844 ppm (1.25) 884 ppm
Cat Boqin et al. 1982 10,500 mg/m3 —– 2 hr 4,127 ppm (1.25) 413 ppm

Human data: It has been stated that a 1-hour exposure to 300 ppm might cause serious effects [Deichmann and Gerarde 1969].

Revised IDLH: 250 ppm

Basis for revised IDLH: The revised IDLH for allyl chloride is 250 ppm based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969] and animals [Boqin et al. 1982].

References:

  1. Boqin L, Shuwei D, Airu Y, Yinlin X, Taibao G, Tao C [1982]. Studies on the toxicity of allyl chloride. Ecotoxicol Environ Safety 6(1):19-27.
  2. Deichmann WB, Gerarde HW [1969]. Allyl chloride. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 86-87.
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