NIOSH Skin Notation Profiles: Methyl Isocyanate
DHHS (NIOSH) Publication Number 2014-145
This skin notation profile presents (1) a brief summary of epidemiological and toxicological data associated with skin contact with MIC and (2) the rationale behind the hazard-specific skin notation (SK) assignment for MIC. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to MIC. A literature search was conducted through April 2014 to identify information on MIC, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function–specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to MIC.