NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2014

The NIOSH List of Hazardous Drugs in Healthcare Settings is a tool designed to assist healthcare workers and employers in identifying which drugs routinely handled by employees are considered by NIOSH to be hazardous drugs.

The NIOSH Alert: Preventing Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings (NIOSH Pub No 2004-165) was first published in 2004. The document identified a sample list of major hazardous drugs. The list was compiled from information provided by four institutions that had generated lists of hazardous drugs for their respective institutions, as well as a list from the Pharmaceutical Research and Manufacturers of America). The 2004 list was updated in 2010, 2012 and 2014, 2016 and 2024. Some of the updates include:

• The 2010 update (NIOSH Pub No 2010—167) added 21 drugs to the original list in the 2004 Alert. Additional information for the 2010 update can be found at Peer review and public comment.
• The 2014 update (NIOSH Pub No 2014—138) added 27 drugs and includes a review of the 2004 list and the consequent removal of 12 drugs that did not meet the NIOSH criteria for hazardous drugs.
• The 2016 update (NIOSH Pub No 2016—161) added 34 drugs and includes a review of the 2004 list. This list includes drugs reviewed by NIOSH from January 2012 to December 2013. Additional information for the 2016 update can be found at Federal Register Notice.
• The 2024 update (NIOSH Pub No 2025—103) added 25 drugs, 12 with manufacturer’s special handling information, and removed 7 drugs.

To obtain a copy of the 2010, 2014 or 2016 versions please contact CDC Info 1-800-CDC-INFO (1-800-232-4636)|TTY: 1-888-232-6348 l cdc.gov/info.

NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2014

Document Development History

Peer review and public comment