Started in 2008, the Human Papillomavirus (HPV) Vaccine Impact Monitoring Project (HPV-IMPACT) monitors rates of high-grade cervical lesions in women in the United States. Scientists use data from the project to determine the impact of the U.S. HPV vaccination program on cervical precancers caused by HPV. High-grade cervical lesions are precancers that could progress to invasive cervical cancer if left untreated.


Since its inception in 2008, HPV-IMPACT has enabled CDC to describe trends in the cervical lesions that could progress to cancer and the reduction of vaccine-preventable cancer-causing HPV types (such as HPV16 and HPV18) in women diagnosed with these cervical lesions.

HPV-IMPACT Surveillance Areas within the Untied States

HPV-IMPACT includes defined areas in five states covering 1.5 million women