Multisystem Inflammatory Syndrome (MIS)
The Council of State and Territorial Epidemiologists (CSTE) and CDC have developed a new CSTE/CDC MIS-C surveillance case definition, corresponding case report form [441 KB, 3 pages], and case report form guidance document [329 KB, 10 pages] to be used starting January 1, 2023. MIS-C cases with illness onset before January 1, 2023, but reported after January 1, 2023, will be assigned using the 2020 CDC MIS-C case definition but reported using the new case report form. An interim case reporting guidance document [181 KB, 4 pages] will be provided for these cases.
MIS and COVID-19
CDC is conducting surveillance and investigations of multisystem inflammatory syndrome in children and adults, a rare but serious condition associated with COVID-19.
What is MIS?
Multisystem inflammatory syndrome (MIS) can affect children (MIS-C) and adults (MIS-A). MIS is a rare but serious condition associated with COVID-19 in which different body parts become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs.
If you or someone in your household is showing any emergency warning signs, seek emergency medical care immediately.
MIS-A (Adults)
What we know, how to protect yourself, what to do if you think you are sick with MIS-A.
CDC has developed a case definition to assist in identification and reporting of MIS-A cases.
MIS-C (Children)
What we know, how to protect your child from MIS-C, what to do if you think your child is sick with MIS-C, and how doctors will care for your child.
Case definition, clinical presentation, case report form, and more resources for healthcare providers.
CDC has been tracking reports of multisystem inflammatory syndrome in children (MIS-C).