Appendix B: Algorithm for Diagnosing and Treatment for Malaria in the United States

At a glance

Algorithm to help make diagnosis and treatment decisions for presenting patients suspected of malaria.

Algorithm for Diagnosis and Treatment of Malaria

If after urgent infectious disease consultation, additional assistance is needed, clinicians can call the CDC Malaria Hotline: (770) 488-7788 or (855) 856-4713 (toll free), Mon–Fri, 9 am–5 pm EST; (770) 488-7100 after hours, weekends, and holidays.

Algorithm for Diagnosis and Treatment of Malaria in the United States


* Treatment for special populations (children and pregnant women) can be found in the CDC Treatment Guidelines and Treatment Table.

** If rapid diagnostic test performed, smear should also be performed with results available as soon as possible.

† If species later identified as P. vivax or P. ovale, add primaquine if not G6PD deficient by quantitative testing. Tafenoquine can only be used if concurrently given with chloroquine or hydroxychloroquine.

‡Drug options for chloroquine-resistant P. falciparum may be used.