THRIVE: Targeted Highly-Effective Interventions to Reverse the HIV Epidemic

Health Department Demonstration Projects for Comprehensive Prevention, Care, Behavioral Health, and Social Services for Men Who Have Sex with Men of Color at Risk for and Living with HIV Infection (CDC-RFA-PS15-1509)


In 2015, 39,513 new HIV infections were diagnosed in the United States. Gay, bisexual, and other men who have sex with men (MSM) were most heavily affected by HIV infection, and black and Hispanic MSM comprised 67% of all new diagnoses among MSM. To address this high disease burden among MSM of color, health departments will implement culturally competent HIV prevention are care interventions to reduce HIV acquisition and transmission, and to improve outcomes along the HIV continuum of care [PDF – 175 KB]. These include antiretroviral (ARV) medications that can be used for HIV preeexposure prophylaxis (PrEP) as a daily medication taken by persons at substantial risk for HIV acquisition, or by persons for HIV nonocupational postexpsoure prophylaxis (nPEP) after a potential exposure. The daily use of PrEP has been demonstrated to reduce the risk of HIV acquisition by greater than 90% among sexually active MSM when taken daily. MSM of color will also benefit from prevention services such as routine HIV testing using strategies to detect acute infection, PrEP adherence support, routine screening for sexually transmitted diseases (STDs), and evidence-based risk reduction interventions. ARV treatment with the goal of viral suppression among persons living with HIV (PLWH) has been demonstrated to significantly reduce the risk of transmission to uninfected sexual partners and to improve health outcomes of infected individuals, and interventions and strategies will be implemented to link, retain, and re-engage PLWH in care and to support their adherence to ARV treatment.


THRIVE supports state and local health department demonstration projects to develop community collaboratives that provide comprehensive HIV prevention and care services for MSM of color. Each health department leads a collaborative that includes funded community-based organizations (CBOs) and other unfunded partners such as health care providers and behavioral health and social services providers in their jurisdictions (Figure 1). The collaborative models developed in THRIVE will be designed and implemented to be sustainable beyond the end of the project period.

Model for THRIVE Community Collaboratives

d.	Collaborative model figure shows that the Health Departments receives funding and then uses at least 25%26#37; of its award to fund collaborative CBOs, healthcare providers, and Behavioral health and social services providers.  The health department will also ensure that all THRIVE services are provided by including unfunded partners in the collaborative.

Collaboration to Provide Comprehensive HIV Prevention and Care Services for MSM of Color

Each health department grantee must fund local CBOs using at least 25% of its award to provide comprehensive HIV prevention and care services and behavioral health and social services for MSM of color. The health department will ensure that all THRIVE services are provided by including unfunded partners in the collaborative.


The THRIVE project ended in 2020. Resources were developed during this successful demonstration project that may be useful to public health partners. Examples of resources include: data management and visualization tools, PrEP educational materials, PrEP navigation tools, and others. Please contact CDC-INFO to inquire about available resources.