B Virus (herpes B, monkey B virus, herpesvirus simiae, and herpesvirus B)
B virus infection is extremely rare, but it can lead to severe brain damage or death if you do not get treatment immediately. People typically get infected with B virus if they are bitten or scratched by an infected macaque monkey, or have contact with the monkey’s eyes, nose, or mouth. Only one case has been documented of an infected person spreading B virus to another person.

Cause and frequency, transmission, symptoms, prevention, first aid and treatment
Steps to take to help prevent infections that can spread from animals to people
Guidance on specimen collection and laboratory testing for diagnosing B virus infection
Groups of people who are more likely to be exposed to macaque monkeys and B virus
Information on diagnosis and treatment recommendations
Additional information regarding B virus and B virus infection

The first indications of B virus infection are typically flu-like symptoms:
- fever and chills
- muscle ache
- fatigue
- headache
You may develop small blisters in the wound or area on your body that had contact with the monkey.
Symptoms typically start within one month of being exposed to a monkey with B virus infection, but could appear in as little as three to seven days.

If you are exposed to a macaque monkey, begin first aid immediately.
- First, thoroughly wash and gently scrub the wound or area on your body that had contact with the monkey with soap, detergent, or iodine for 15 minutes.
- After, run water over the wound or area for 15 to 20 minutes more.
Then, immediately see a healthcare provider for treatment. Tell the healthcare provider that you have been exposed to a macaque monkey that may be infected with B virus.