Rush University Prevention Epicenter

First Funded: 2006

Overview: Rush University’s Chicago Prevention and Intervention Epicenter III (CPIE-III) has projects designed to protect people from catching hard-to-treat germs in all types of healthcare facilities.

CDC Prevention Epicenters - innovative research to protect patients

About this Epicenter

The Chicago Prevention and Intervention Epicenter research includes an ambitious portfolio of projects in hospitals, long-term acute care hospitals (LTACHs), and skilled nursing facilities. CPIE-III makes epidemiologic and basic science discoveries and technological innovations translatable into strategies to prevent the spread of antimicrobial-resistant (AR) organisms both within facilities and regionally across interconnected facilities. Multiple interventions are applied across different types of healthcare facilities to control endemic AR pathogens and mitigate emerging, novel resistance mechanisms.

Core Research Study Areas

Diverse interventions are needed in all settings; therefore, the Chicago Prevention and Intervention Epicenter III (CPIE-III) evaluates four areas:

  1. How a patient’s own microbes can protect them or may make them vulnerable
  2. How germs spread between people using advanced genetic analyses
  3. Data exchange among facilities, and
  4. Measures of antibiotic use across facilities.

Core research study areas include:

  • Predictive modeling to identify patients at high-risk for Multidrug-resistant organisms (MDROs) to inform Illinois’ Extensively Drug-Resistant Organism (XDRO) registry
  • Regional active MDRO surveillance with genomic analysis
  • Geospatial, ecologic, and clinical risk factors for community-associated extended spectrum beta-lactamase producers. Genomic epidemiology of MDRO transmission in Intensive Care Units (ICUs) applying innovative research methodology to evaluate MDRO transmission
  • Adverse health outcomes associated with microbiota disruption
  • Generate and export reports on antimicrobial use metrics from a national common data model

Multicenter Collaborative Research Projects

  • Dynamics of the microbiota and resistome in ICU patients
  • Chlorhexidine effectiveness assessment in non-ICU hematology-oncology/bone marrow transplantation units (CLEAN-HEME)

Principal Investigator

Mary Hayden, MD and William Trick, MD