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Evidence-Based Recommendations—GRADE

See complete list of GRADE materials linked from MMWR


CDC vaccine recommendations are developed using an explicit evidence-based method based on the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Key factors considered in development of recommendations include balance of benefits and harms, type or quality of evidence, values and preferences of the people affected, and health economic analyses.

  • Category A recommendations are made for all persons in an age- or risk-factor-based group.
  • Category B recommendations are made for individual clinical decision making.
  • Evidence tables are used to summarize the benefits and harms and the strengths and limitations of the body of evidence.

Resources for Learning More About GRADE

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