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Tuberculosis Trials Consortium (TBTC)

The TBTC is a collaboration of researchers from the CDC, domestic and international public health departments, academic medical centers, and selected Veterans Administration medical centers whose mission is to conduct programmatically relevant research concerning the diagnosis, clinical management, and prevention of tuberculosis (TB) infection and disease. The purposes of the TBTC are to conduct research that expands clinical and epidemiologic knowledge of TB and facilitates the diagnosis, clinical management, and prevention of tuberculosis infection and disease; to integrate research into the care of persons with TB infection and disease; to develop research questions that are relevant to program settings in general; to promote research within local TB control programs through collaboration on clinical research of relevance to public health settings; and to provide a forum for international collaborative research of importance to both domestic and international TB control.

Since its inception, the Tuberculosis Trials Consortium (TBTC) has undertaken nine major trials and 15 sub-studies. The completed TBTC studies have resulted in 25 publications in peer-reviewed journals, as well as over 100 presentations, posters, and abstracts at major medical or scientific meetings. The results of TBTC Study 22 significantly influenced the most recent American Thoracic Society (ATS)/CDC guidelines for treatment of TB (published in 2003); other TBTC study results have led to modification of CDC’s recommendations for treatment of TB and HIV.