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giardia trophozoites

Giardia trophozoites. Credit: Waterborne Disease Prevention Branch, CDC

Giardia cyst in wet mount.

Wet mount of a Giardia cyst. Credit: Waterborne Disease Prevention Branch, CDC

Giardiasis is a diarrheal illness caused by the parasite Giardia intestinalis (also known as Giardia lamblia or Giardia duodenalis). A parasite is an organism that feeds off of another to survive.

Giardiasis is a global disease. It infects nearly 2% of adults and 6% to 8% of children in developed countries worldwide. Nearly 33% of people in developing countries have had giardiasis. In the United States, Giardia infection is the most common intestinal parasitic disease affecting humans[1].

People become infected with Giardia by swallowing Giardia cysts (hard shells containing Giardia) found in contaminated food or water. Cysts are instantly infectious once they leave the host through feces (poop)[2]. An infected person might shed 1-10 billion cysts daily in their feces (poop) and this might last for several months[2,6,7]. However, swallowing as few as 10 cysts might cause someone to become ill[2,6]. Giardia may be passed person-to-person or even animal-to-person[2,3]. Also, oral-anal contact during sex has been known to cause infection[4,5]. Symptoms of giardiasis normally begin 1 to 3 weeks after a person has been infected[6].

Giardia infection rates have been known to go up in late summer[8-10]. Between 2006-2008 in the United States, known cases of giardiasis were twice as high between June-October as they were between January-March[2].

Anyone may become infected with Giardia. However, those at greatest risk are[2,11-16]:

  • Travelers to countries where giardiasis is common
  • People in child care settings
  • Those who are in close contact with someone who has the disease
  • People who swallow contaminated drinking water
  • Backpackers or campers who drink untreated water from lakes or rivers
  • People who have contact with animals who have the disease
  • Men who have sex with men
Reference
  1. Kappus KD, Lundgren RG, Jr., Juranek DD, Roberts JM, Spencer HC. Intestinal parasitism in the United States: update on a continuing problem. Am J Trop Med Hyg. Jun 1994;50(6):705-713.
  2. Yoder JS, Harral C, Beach MJ. Giardiasis surveillance - United States, 2006-2008. MMWR Surveill Summ. Jun 11 2010;59(6):15-25.
  3. Robertson LJ, Hanevik K, Escobedo AA, Morch K, Langeland N. Giardiasis--why do the symptoms sometimes never stop? Trends Parasitol. Feb 2010;26(2):75-82.
  4. Escobedo AA, Cimerman S. Giardiasis: a pharmacotherapy review. Expert Opin Pharmacother. Aug 2007;8(12):1885-1902.
  5. Pakianathan MR, McMillan A. Intestinal protozoa in homosexual men in Edinburgh. Int J STD AIDS. Dec 1999;10(12):780-784.
  6. Rendtorff RC. The experimental transmission of human intestinal protozoan parasites. II. Giardia lamblia cysts given in capsules. Am J Hyg. Mar 1954;59(2):209-220.
  7. Danciger M, Lopez M. Numbers of Giardia in the feces of infected children. Am J Trop Med Hyg. Mar 1975;24(2):237-242.
  8. Naumova EN, Jagai JS, Matyas B, DeMaria A, Jr., MacNeill IB, Griffiths JK. Seasonality in six enterically transmitted diseases and ambient temperature. Epidemiol Infect. Feb 2007;135(2):281-292.
  9. Naumova EN, Chen JT, Griffiths JK, Matyas BT, Estes-Smargiassi SA, Morris RD. Use of passive surveillance data to study temporal and spatial variation in the incidence of giardiasis and cryptosporidiosis. Public Health Rep. Sep-Oct 2000;115(5):436-447.
  10. Greig JD, Michel P, Wilson JB, et al. A descriptive analysis of giardiasis cases reported in Ontario, 1990-1998. Can J Public Health. Sep-Oct 2001;92(5):361-365.
  11. Thompson RC. Giardiasis as a re-emerging infectious disease and its zoonotic potential. Int J Parasitol. Nov 2000;30(12-13):1259-1267.
  12. Birkhead G, Vogt RL. Epidemiologic surveillance for endemic Giardia lamblia infection in Vermont. The roles of waterborne and person-to-person transmission. Am J Epidemiol. Apr 1989;129(4):762-768.
  13. Hoque ME, Hope VT, Scragg R, Kjellstrom T, Lay-Yee R. Nappy handling and risk of giardiasis. Lancet. Mar 31 2001;357(9261):1017-1018.
  14. Esfandiari A, Swartz J, Teklehaimanot S. Clustering of giardiosis among AIDS patients in Los Angeles County. Cell Mol Biol (Noisy-le-grand). Nov 1997;43(7):1077-1083.
  15. Welch TP. Risk of giardiasis from consumption of wilderness water in North America: a systematic review of epidemiologic data. Int J Infect Dis. 2000;4(2):100-103.
  16. Stuart JM, Orr HJ, Warburton FG, et al. Risk factors for sporadic giardiasis: a case-control study in southwestern England. Emerg Infect Dis. Feb 2003;9(2):229-233.
 
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