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| NIOSH Home > Safety and Health Topics >Skin Exposures and Effects >Occupational & Environmental Exposures of Skin to Chemicals- 2005> Abstracts |
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Workshop 2: Quantitative Risk Assessment Co-Chairs: Workshop 2 will focus on the pertinent issues by bringing ideas and experimental data of researchers in these fields together in order to bridge the gap between exposure measurement and the assessment of dermal uptake of chemicals for risk assessment. A white paper titled "Dermal exposure and uptake of chemicals for systemic risk assessment" was written as a background document for all participants. View it here. In earlier plenary presentations by Dr. Nick Warren and by Prof. Richard Guy, the relevant issues for dermal exposure assessment and for dermal penetration will have been presented with focus on the need for bridging. The workshop itself will start with a series of short and focussed presentations covering the more detailed issues relevant for the bridging of the gap. These presentations will also cover the important variables that should be considered when assessing the relevance of dermal exposure data for penetration. For this goal, three well-known researchers have been asked to highlight some important issues in very short presentations which may then form the basis of discussions. Dr. Derk Brouwer will cover temporal and spatial patterns of exposure versus dose. Dr. John Cherrie will cover QSAR methodology – uses and limitations. Prof. Annette Bunge will cover the characterisation of surface loadings/concentration – vehicle, distribution, skin condition, and measurement approaches. All speakers will prepare in advance, at least two statements which will stimulate and focus the discussions on how to integrate external exposure and absorption data in an optimal way. On the basis of the results of the workshop, a posterior white paper will be developed for further discussions and research.
Content last modified: 21 April 2005
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