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Workshop Discussions
Summary of questions appropriate
for discussion in the Workshop Session “Health Effects and Hazard Identification”(Toxicological
Aspects)
- 1. Is this outline of Opportunities
for Effective Action a useful guide for the discussion in this Workshop
Session? What are some of the most significant ways in which it can
be improved?
2. From the Opportunity for Effective Action by Individuals/Employers/Supervisors/Insurers/Site
Owners maintaining a safe and healthful site:
a. Are there readily understandable information sources about chemicals
or tasks identifying health effects in general terms? List at I.C.2.i
…
b. Specifically, do these potential actors have enough information
about the meaning of the skin notations adopted in different countries
and the fact that they do not include irritants and corrosives?
3. From the Opportunity for Manufacturers/Distributors to take effective
actions to maintain product stewardship:
a. Are there internationally recognized symbols to communicate dermal
risk? If so, are they appropriate and based on sound scientific knowledge?
b. Which products should be tested for dermal risk before commercialization?
What level of assurance do these tests provide to workers and the
general population about the risk of using those products?
4. From the Opportunity for Clinicians to take effective action to evaluate
and promote the health of individuals or populations:
a. Currently, how often are investigative or preventive actions initiated
after recognition of cases of irritant/allergic dermatitis that might
be due to occupational or environmental exposure?
b. Is improved collaboration between dermatologists, occupational/environmental
hygienists, occupational/environmental physicians and toxicologists
important in identifying dermal hazards? If so, how could improved
collaboration be accomplished?
5. From the Opportunity for National or International Bodies to take
effective action by outlining technical requirements or recommendations:
a. Are there lists of sources of appropriate summary health effect
and toxicological information about chemicals? List at IV.C.2.a.i
…
b. Are there protocols for literature searches for this type of information?
List at IV.C.2.b.i …
c. Are there protocols for characterizing the corrosivity of a chemical
or mixture? List at IV.C.2.c.i …
d. Are there protocols for characterizing irritation potential of
a chemical or mixture? List at IV.C.2.d.i …
e. Are there protocols for characterizing sensitization potential
of a chemical or mixture? List at IV.C.2.e.i …
f. Are there protocols for characterizing potential for a chemical
or mixture to cause systemic effects after dermal exposure? List at
IV.C.2.f.i …
g. Are there protocols for making relevant measurements of skin permeation
rates and reservoir effects? List at IV.C.2.g.i …
h. Are there any situations in which the properties of the chemical
and the conditions of the exposure lead to no chemical or derivatives
interacting with living tissue? If so, these situations should be
highlighted as ones in which there is no possibility of harm to health
due to chemical exposure of the skin.
i. Is the current skin notation system appropriate to warn of potential
harm due to dermal exposure?
j. Are there simplifications/standardizations that might make the
Dermal Occupational Exposure Limit approach more feasible?
6. Within the scope of this Workshop Session, what is the relative importance
of:
a. doing a better job of applying existing data using existing decision-making
procedures,
b. obtaining new data using accepted data-gathering protocols,
c. developing better data-gathering protocols and
d. developing better decision-making procedures
in order to improve the outputs from each step of an Opportunity for
Effective Action?
7. What research is likely to have the most impact on improving the
ability of various actors to take effective actions?
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