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| NIOSH Home > Safety and Health Topics >Skin Exposures and Effects >Occupational & Environmental Exposures of Skin to Chemicals- 2005> Abstracts |
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Experimental prediction of percutaneous penetration Faith Williams Percutaneous penetration of chemicals through the skin represents a pathway that may be significant compared to inhalation but is often incorrectly estimated. It is necessary to quantitatively assess the potential for systemic exposure by this route when making risk assessments. Methods used include skin deposition measurements, in vivo studies with biological monitoring, in vitro systems with isolated skin and predictive modelling and Quantitative Structure Activity Relationships (QSAR) approaches. This short course will introduce participants to the principles of dermal exposure, and factors influencing dermal penetration. Methods for determining dermal absorption and for presentation of results will be described and the pros and cons of in vitro methods discussed. Studies of the robustness of in vitro methods and their ability to predict dermal penetration in vivo will be discussed. The use of in vitro data for risk assessment and as support for predictive models will also be addressed. Content last modified: 14 May 2005 |
