|
|
|
|
|
|
|
|
| NIOSH Home > Safety and Health Topics >Skin Exposures and Effects >Occupational & Environmental Exposures of Skin to Chemicals- 2005> Abstracts |
|
|
 |
||||||||||||||||||||||||
Recommendations from the CEFIC International Workshop on methods to determine dermal permeation of industrial chemicals for human risk assessment
A.D. Jones*1, I.P: Dick2, J.W Cherrie1, M.T.D. Cronin3, J.J.M. van de Sandt4, D.J. Esdaile5, S. Iynegar6, W. ten-Berge7, S.C. Williams8, C.S. Roper9, S. Semple10, C. de Heer4, F. Williams8 Background
The European Commission proposal (REACH) will require extensive risk assessments of all existing chemicals, including for exposure via dermal contact. Methods
The international workshop, supported by CEFIC (European Chemical Industry Council), brought relevant expertise together for the purpose of recommending a standardised protocol for in vitro determination of permeability coefficients for industrial chemicals. Recommendations achieved at the meeting were refined through comment on draft reports and protocols. Results
The workshop agreed that it is impractical to measure dermal permeation coefficients for the many thousands of industrial chemicals in use. An alternative approach is to base predictions of permeation on statistically derived relationships between physico-chemical properties and the permeability coefficient of representative chemicals, QSARs. However, existing QSARs have been derived from data obtained by a variety of experimental methods, which makes the prediction less reliable. The reliability is to be improved by using a standardised experimental protocol. Conclusions
The proposed protocol is intended, in the first instance, for testing aqueous soluble chemicals only. The Workshop also proposed a strategy to extend the scope of the methodology to the full range of industrial chemicals, and made recommendations for the use of the permeability coefficients in risk assessment.
Content last modified: 17 May 2005 |
