ASTHMA & ALLERGIES
Exacerbation of Asthma Research
NIOSH Leads Research on Workplace Exacerbation of Asthma
A 2003 statement of the American Thoracic Society (ATS) included the observation that asthma exacerbated by conditions at work was likely to be responsible for as much illness and loss of productivity as asthma caused by work. However, workplace exacerbation of asthma (WEA) had received little attention from clinicians, researchers, and public health officials. More research on the frequency and causes of WEA was needed to guide preventive actions. Dr. Paul Henneberger and others in the Respiratory Disease Research Program (RDRP) at NIOSH recognized this need several years ago and took action. Initially, they conducted descriptive studies of WEA by collaborating with research institutions in Maine and Colorado, and by summarizing data collected by NIOSH-supported SENSOR surveillance programs in California, Massachusetts, Michigan, and New Jersey. Then, they successfully competed for National Occupational Research Agenda (NORA) funds that supported a 5-year study of WEA. This NORA research project also benefited from additional financial support from the National Center for Environmental Health. As of December 2010, the RDRP has produced more publications on WEA than any other research center in the world, with 9 articles in peer-reviewed journals, two book chapters, and an online educational unit (see below). The findings from several of these articles indicate that WEA is common, occurring in approximately one-fourth of working adults with asthma. Also, WEA cases experience many of the same adverse health consequences as individuals with asthma caused by work, and have a lower quality of life than adults who have asthma that is not related to work. Additional research and communication efforts are needed to prevent WEA. Dr. Paul Henneberger chairs the ATS Work-Exacerbated Asthma Committee that is developing an official ATS statement on this topic.
NIOSH Publications on Workplace Exacerbation of Asthma
Articles in Peer-reviewed Journals
- Bolen AR, Henneberger PK, Liang X, et al. The validation of work-related self-reported asthma exacerbation. Occup Environ Med,2007; 64:343-348.
- Goe SK, Henneberger PK, Reilly MJ, et al. A descriptive study of work-aggravated asthma. Occup Environ Med, 2003; 61:512-517.
- Henneberger PK, Hoffman CD, Magid DJ, Lyons EE. Work-related exacerbation of asthma. Int J Occup Environ Health, 2002;8:291-296.
- Henneberger PK, Deprez RD, Asdigian N, et al. Workplace exacerbation of asthma symptoms: findings from a population-based study in Maine. Arch Env Hlth, 2003; 58:781-788.
- Henneberger PK, Derk SJ, Sama SR, et al. The frequency of workplace exacerbation among health maintenance organization members with asthma. Occup Environ Med, 2006; 63:551-557.
- Henneberger PK. Work-Exacerbated Asthma. Current Opinion in Allergy and Clinical Immunology, 2007; 7(2):146-151.
- Henneberger PK, Mirabelli MC, Kogevinas M, et al. The occupational contribution to severe exacerbation of asthma.Eur Respir J, 2010;36(4):743-50.
- Lowery EP, Henneberger PK, Rosiello R, Sama SR, Preusse P, Milton DK. Quality of life of adults with workplace exacerbation of asthma. Qual Life Res, 2007;16:1605-1613.
- Vandenplas O, Henneberger PK. Socioeconomic outcomes in work-exacerbated asthma. Curr Opin Allergy Clin Immunol, 2007; 7:236-241.
- Wagner GR, Henneberger PK. Asthma Exacerbated at Work. In: Bernstein DI, Chan-Yeung M, Malo J-L, Bernstein IL, editors. Asthma in the Workplace and Related Conditions, 3rd Edition. New York:Taylor and Francis, 2006, pp 631-640.
- Henneberger PK, Redlich CA. Work-exacerbated asthma. In: Sigsgaard T, Heederik D, editors. Occupational Asthma. Basel, Switzerland: Birkhäuser, 2010, pp 89-100.
- Henneberger PK. Work-Exacerbated Asthma. Pulmonary and Critical Care Updates (PCCU), Lesson 13, Volume 23, 2009.
- National Institute for Occupational Safety and Health (NIOSH)
- Centers for Disease Control and Prevention
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