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Manufacturing

NORA Manufacturing Sector Strategic Goals

927ZHMY - Criteria Document: Diacetyl

Start Date: 10/1/2008
End Date: 9/30/2014

Principal Investigator (PI)
Name: Lauralynn Taylor
Phone: 513-533-8542
E-mail: ldt4@cdc.gov
Organization: NIOSH
Sub-Unit: EID
Funded By: NIOSH

Primary Goal Addressed
5.0

Secondary Goal Addressed
8.0


Attributed to Manufacturing
100%

Project Description

Short Summary

The purpose of this document is to develop a Criteria document with a recommended exposure limit for diacetyl and 2,3 pentanedione. The Criteria document provides a forum to review new scientific information, develop a recommended exposure limit, and provide guidance to stakeholders, public health agencies and regulatory agencies. The breadth of information contained in the Criteria document would likely be used by regulatory agencies in their rulemaking efforts for diacetyl.

This project supports the NIOSH program portfolio by focusing on the Respiratory Diseases Cross Sector, as well as the Manufacturing Sector program.

The diacetyl criteria document provides a forum to review new scientific information, develop a recommended exposure limit, and provide guidance to stakeholders, public health agencies and regulatory agencies. The breadth of information contained in the Criteria document would likely be used by regulatory agencies in their rulemaking efforts for diacetyl. The hazard guidance provided in the Criteria document could help our targeted audience develop and implement engineering controls, improved work practices, medical surveillance, and respiratory protection programs to subsequently reduce occupational exposures and potentially prevent disease.



Description

The purpose of the Diacetyl Criteria document is to evaluate and analyze the scientific literature concerning potential health effects, toxicology, engineering controls, work practices, personal protective equipment and recommendations pertaining to diacetyl and other flavorings substances. After reviewing data from previously published studies and NIOSH reports, the document aims to:

1) Develop and provide the basis for a Recommended Exposure Limit to Diacetyl and 2,3-pentanedione;
2) Update the state of the art science included in the document entitled NIOSH Alert: Preventing Lung Disease in Workers Who Use or Make Flavorings (Publication No. 2004110), produce information products as appropriate; and
3) Reduce occupational exposures to diacetyl, 2, 3-pentanedione and other flavoring substances and thereby prevent flavoringinduced lung disease through hazard guidance implementation.

This project will result in the publication of a criteria document with a recommended exposure limit for diacetyl and 2, 3- pentadione. This document will be published for peer and public comment/review in 2011.



Mission Relevance

Occupational exposures in the flavoring and food production industry have been associated with flavorings related lung disease including bronchiolitis obliterans (BO), a rare lung disease characterized by fixed airways obstruction. Occurrences of BO were observed in the microwave popcorn industry in 2000 when eight workers, formerly employed in a microwave popcorn facility, were diagnosed with the disease. Since this time, numerous cases of BO have been observed in the microwave popcorn industry. More recently, two workers involved in the production of flavorings in California were diagnosed with BO and five additional flavor-manufacturing workers were identified with severe fixed obstructive lung disease Employees within the flavoring and food production industry have complex exposures in terms of the physical form and the number of different chemicals used. Although there are thousands of flavoring compounds in use, only a small number have occupational exposure limits. Consequently a comprehensive review and analysis of occupational exposures to diacetyl and the development of a recommended exposure limit (REL) will provide valuable information. Additionally, the criteria document will provide hazard guidance that is critical to reducing the risk of flavoring-related lung disease.

According to U.S. Census data from 2002, there were approximately 21,000 employees working in flavoring production. Additionally, the employment figures for the food production industry suggest that over 500,000 workers have potential exposure to diacetyl and other food flavorings from employment in Bakeries and Tortilla Manufacturing, Dairy Product Manufacturing, Sugar and Confectionery Product Manufacturing and Other Food Manufacturing. The target groups will be owners, managers, and workers in the flavoring manufacturing and food production industries. An additional audience would be public health agencies that provide guidance to these stakeholders as well as the regulatory agencies engaged in rulemaking efforts regarding diacetyl.

The purpose of this document is to develop a Criteria document with a recommended exposure limit for diacetyl and 2,3 pentanedione. The Criteria document provides a forum to review new scientific information, develop a recommended exposure limit, and provide guidance to stakeholders, public health agencies and regulatory agencies. The breadth of information contained in the Criteria document would likely be used by regulatory agencies in their rulemaking efforts for diacetyl. The hazard guidance provided in the Criteria document could help our targeted audience develop and implement engineering controls, improved work practices, medical surveillance, and respiratory protection programs to subsequently reduce occupational exposures and potentially prevent disease.



Page last updated: June 3, 2011
Page last reviewed: May 23, 2011
Content Source: National Institute for Occupational Safety and Health (NIOSH) Office of the Director

 

NIOSH Program:

Manufacturing