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Appendix H: Search Strategy for Literature Addressing Development of HCC among Persons with HCV Who Either Achieve an SVR or Have No Response to Treatment,* by Database



Database

Search terms

No. hits

Dates covered

MEDLINE

1. Hepatitis C[mesh] or "hepatitis c"
OR "hep c" OR HCV

1. 57,231

1946–02/2012

2. HCC OR hepatocellular

2. 71,033

3. #1 AND #2

3. 6,788

4. Treatment OR therapy OR treat* OR therap*

4. 7,698,358

5. #3 AND #4

5. 3,717

6. Limit 5 to English language

6. 3,238

Total: 3,275

De-duplicated§: 3,273

EMBASE (Ovid)

1. (hcc or hepatocellular carcinoma).mp

1. 46,546

1988–02/2012

2. Limit #1 to English language

2. 38,765

3. (hepatitis c or hep c or hcv).mp

3. 80,415

4. #2 and #3

4. 7,359

5. (treatment or therapy).mp

5. 3,710,093

6. #4 and #5

6. 3,414

Total: 3,439

De-duplicated§: 1,483

Web of Science

1. Topic=(hcc OR hepatocellular) AND topic=("hepatitis c" OR hep-c OR hcv)

1. 8,352

1950–02/2012

2. Limit #1 to English language

2. 8,069

3. Topic=(treatment OR therapy)

3. 2,908,801

4. #3 AND #2

4. 3,290

Total: 3,317

De-duplicated§: 1,421

CINAHL

1. (Hep c OR hep-c OR hepatitis-c OR hepatitis C) AND (HCC or hepatocellular) AND (treatment OR therapy)

1. 198

1937–2012

De-duplicated§: 54

Cochrane

1. Hepatitis c OR hcv OR hepc OR hepatitis-c OR hep-c

Cochrane Reviews: 3

2012

2. HCC OR hepatocellular

Other Reviews: 10

Clinical Trials: 177

Methods Studies: 1

Technical

Assessments: 1

Economic Evaluations: 7

Total: 199

De-duplicated§: 69

Database of Abstracts of Reviews and Effects

1. (hcc OR hepatocellular) AND (hepatitis-c OR hepc OR hep-c OR hepatitis c OR hcv)

1. 152

De-duplicated§: 107

2012

Abbreviations: HCC = hepatocellular carcinoma; HCV = hepatitis C virus; SVR = sustained viral response.

* This literature search was conducted to determine the effect of a birth-year-based testing strategy versus the standard of care (i.e., risk-based testing).

Search totals were updated in February 2012.

§ The number of reports remaining after duplicate study reports were identified.


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