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Notice to Readers: Update: Vol. 47, No. 9

In the report, "Human Exposure to Brucella abortus Strain RB51 --- Kansas, 1997," the sixth paragraph of the Editorial Note (page 174) mentioned efforts by CDC's Special Bacteriology Reference Laboratory to develop a polymerase chain reaction assay for detection of human RB51 infection. However, currently no validated routine test is available to monitor infections associated with exposure to the RB51 vaccine strain. Exposure to RB51 does not elicit a measurable antibody response; therefore, serology cannot provide an indicator of infection. Persons seeking assistance in identifying Brucella spp. or serologic monitoring of exposed persons should contact their state health departments or the CDC Bacterial Special Pathogens Branch at telephone 404-639-1711.

Postexposure prophylaxis is recommended for persons at high risk. A high-risk exposure is defined as 1) having direct personal exposure to Brucella (e.g., sniffing bacteriologic cultures, direct skin contact, pipetting by mouth, inoculation, or spraying into the eyes, nose, or mouth), 2) performing work on an open bench (i.e., outside of biosafety level 3 containment equipment) with an open culture plate containing a Brucella isolate or being in close proximity to such work (e.g., across an open bench top or within 5 feet), or 3) presence in the laboratory during any procedure conducted on a Brucella isolate that might result in generation of aerosolized organisms and inhalational exposure (e.g., vortexing or catalase testing).



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