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Awarded Grant - Acute Care

An Investigation of Outcomes Associated with Pediatric TBI

FOA Number: CE04-044 - Grants for Acute Care, Rehabilitation, and Disability Prevention Research
Project Period: 08/01/04 – 07/31/07
Application/Grant Number: 5-R49-CE000394-03
Principal Investigator: Jeanne E. Dise-Lewis, PhD
University of Colorado Health Sciences Center
The Children’s Hospital
1056 East 19th Avenue, B285
Denver, CO 80218
Phone: 303-861-6642
Fax: 303-764-8048


Traumatic Brain Injury (TBI) is the leading cause of both death and disability for children and youth in the United States. Half of the estimated 5.3 million persons in the United States who have TBI are under age 18. Each year, approximately 3,000 children die from TBI and 29,000 of them survive injuries in the moderate to severe range. Approximately 30,000 children are permanently disabled annually as a result of TBI, which significantly impacts their physical, cognitive, and psychosocial competencies. An estimated additional 900,000 children have "mild" TBIs each year; the impact of these injuries on development and learning is largely unknown, but potentially significant.

The University of Colorado Health Sciences Center (UCHSC) and The Children's Hospital, Denver will conduct a comprehensive, longitudinal study of the course of mild, moderate, or severe TBI, from initial injury through long-term community reintegration. Researchers will also conduct a randomized, controlled comparison of four interventions to assess the impact on long-range psychosocial outcomes. This study will establish a comprehensive database of variables related to psychosocial TBI outcomes in children and youth and establish interventions that may improve these outcomes. The UCHSC will work closely with the Colorado Department of Health's Programs for Children with Special Healthcare Needs.