Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Awarded Grant - Acute Care

Epidemiology and Costs of Mild Traumatic Brain Injury in Nonhospitalized Patient Populations

FOA Number: CE02-127: Grants for Acute Care, Rehabilitation, and Disability Prevention Research
Project Period: 9/30/02 – 9/29/05
Application/Grant Number: R49-CCR922432-01
Principal Investigator: Jess Kraus, MPH, PhD
Regents of the University of California
10920 Wilshire Boulevard, Suite 1200
Los Angeles, CA 90024
Phone: 310-794-2706
Fax: 310-794-0787


This research examines the incidence, costs, and long-term consequences of mild traumatic brain injury (MTBI) among population-based patient groups presenting to two trauma centers and three non-trauma-designated hospitals in San Diego County, California. The following specific aims will accomplish this objective:

  1. Estimate by patient demographics and mechanism of injury the rate of MTBI occurring in two trauma center catchment areas and three non-trauma-designated emergency department service areas.
  2. Estimate the medical expenditures associated with MTBI and the indirect costs of lost work and household production time;
  3. Describe the 3- and 6-month outcomes experienced by MTBI patients, compared with patients with an injury not sustained to the head, controlling for patient demographics and pre-morbid conditions.
    This research will describe the natural course of MTBI in non-hospitalized patient groups where little research has been concentrated. A prospective cohort study design will be used to identify, enroll, and follow non-hospitalized MTBI patients who present to the participating facilities. The target populations of interest will be patients diagnosed with MTBI who are not admitted to the hospital and patients with an injury to a body region other than the head who are not admitted to the hospital. Posttraumatic outcomes of MTBI will focus on both personal disabilities and those that affect how the MTBI patient interacts and functions in the environment. Researchers will use hospital records, emergency medical service reports, and patient interviews to obtain information about the medical and rehabilitative services received by each enrolled patient and the pre-injury factors, costs, and post-injury outcomes needed to document the natural course of MTBI. Both tabular analysis and longitudinal regression modeling will be used to compare outcomes across the target population groups.