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Awarded Grant - Acute Care

Depression After Mild to Moderate TBI

FOA Number: CE01-013: Grants for Acute Care of Injured Patients
Project Period: 9/30/01–9/29/05
Application/Grant Number: R49-CCR612707-06
Principal Investigator: Harvey S. Levin, PhD
Baylor College of Medicine
One Baylor Plaza
Houston, TX 77030
Phone: 713-798-7566
Fax: 713-798-6898


Patients with mild to moderate traumatic brain injury (TBI) often develop secondary conditions including major depressive disorder (MDD), post-concussive disorder (PCD), or post-traumatic stress disorder (PTSD) within 6 months after injury. This study determines if case management of TBI patients during the first 3 months after injury can decrease the occurrence of secondary conditions. Year 1 of the study identifies and assesses TBI patients at risk for developing secondary conditions. Years 2 and 3 of the study randomize TBI patients at risk for developing secondary conditions into case management and standard care management groups. Outcome measures include the Structured Clinical Interview for DSM-IV, the CES-D, the Visual Analog Scale of Depression, a post-concussion symptom checklist, the PTSD Checklist, a series of cognitive tests, the extended Glasgow Outcome Scale, Community Integration Questionnaire, and the SF-36.